The VanNieuwenhze Group

Patents

---

Patent Applications

1. Brown, P. B.; Brun, Y. V.; Hall, E. A.; Hughes, V.; Kuru, E.; Tekkam, S.; VanNieuwenhze, M. S. “Compositions for Covalently Labeling Bacterial Cell Walls with Fluorophores and Methods of Use Thereof,” United States Patent Application No. 14/395,815, filed October 20, 2014.
2. Brun, Y. V.; Kuru, E.; VanNieuwenhze, M. S. “D-Ala-D-Ala-based Dipeptides as Tools for Imaging Peptidoglycan Biosynthesis,” International Patent Application No. PCT/US2014/055177 filed September 11, 2014.
3. Zlotnick, A.; VanNieuwenhze, M. S.; Turner, W. W.; Li, L. “Fluorescent HAP:  A Diagnostic Stain for HBV Cores in Cells,” International Patent Application No. PCT/US2014/031326; filed March 20, 2014.
4. Zlotnick, A.; VanNieuwenhze, M. S.; Turner, W. W.; Li, L. “Small Molecule Assembly Effectors with Antiviral Properties,” United States Provisional Patent Application No. 61/952, 467 filed March 13, 2014.
5. Brun, Y. V.; Kuru, E.; VanNieuwenhze, M. S. “D-Ala-D-Ala-based Dipeptides as Tools for Imaging Peptidoglycan Biosynthesis,” United States Provisional Patent Application No. 61/876,710, filed September 11, 2013.
6. VanNieuwenhze, M. S.; Turner, W. W.; Witztum, J. L.; Hartvigsen, K. “Peptide Conjugates of Phospholipid Analogs,” United States Patent Application No. 13/983,435, filed September 10, 2013.
7. Brown, P. B.; Brun, Y. V.; Hall, E. A.; Hughes, V.; Kuru, E.; Tekkam, S.; VanNieuwenhze, M. S. “Compositions for Covalently Labeling Bacterial Cell Walls with Fluorophores and Methods of Use Thereof,” PCT Patent Application No. PCT/US2013/035704, filed April 21, 2013.
8. Zlotnick, A.; Li, L.; VanNieuwenhze, M.; Turner, W. “Fluorescent-HAP:  A Diagnostic Stain for HBV Cores in Cells,” United States Provisional Patent Application No. 61/803,554, filed March 20, 2013.
9. VanNieuwenhze, M. S.; Brun, Y. V.; Kuru, E. “D-Amino Acid-based Antibacterial Agents and Methods of Use Thereof,” United States Provisional Patent Application No. 61/783,863, filed March 14, 2013.
10. Zlotnick, A.; Li, L.; VanNieuwenhze, M. S.; Turner, W. W. “Small Molecule Assembly Effectors with Antiviral Properties,” United States Provisional Patent Application No. 61/779,655 filed March 13, 2013.
11. Brown, P. B.; Brun, Y. V.; Hall, E. A.; Hughes, V.; Kuru, E.; Tekkam, S.; VanNieuwenhze, M. S. “Compositions for Covalently Labeling Bacterial Cell Walls with Fluorophores and Methods of Use Thereof,” United States Provisional Patent Application No. 61/718,048, filed October 24, 2012.
12. Brown, P. B.; Brun, Y. V.; Hall, E. A.; Hughes, V.; Kuru, E.; Tekkam, S.; VanNieuwenhze, M. S. “Compositions for Covalently Labeling Bacterial Cell Walls with Fluorophores and Methods of Use,” United States Provisional Patent Application No. 61/636,640, filed April 21, 2012.
13. VanNieuwenhze, M. S.; Turner, W. W.; Witztum, J. L.; Hartvigsen, K. “Peptide-Phospholipid Conjugates,” PCT Patent Application No. PCT/US2012/021819, filed January 19, 2012.
14. VanNieuwenhze, M. S.; Turner, W. W.; Witztum, J. L.; Hartvigsen, K. “Peptide Conjugates of Phospholipid Analogs,” United States Provisional Patent Application No. 61/440,231, filed February 7, 2011.
15. Alborn, Jr., W. E.; Blaszczak, L. C.; Mauldin, S. C.; Skatrud, P. L.; VanNieuwenhze, M. S.; Zia-Ebrahimi, M. S. “Process for Preparing Dansylated Glycopeptide Lipid II Derivatives as Substrates for the Transglycosylase Enzymes,” PCT Intl. Appl. (2002), WO 085929 (A1), Eli Lilly and Company, October 31, 2002
16. Blaszczak, L. C.; Dingess-Hammond, E. A.; Hornback, W. J.; VanNieuwenhze, M. S. “Preparation of Glucosaminyl-b-[1, 4]-N-Acetylmuramic Acid Derivatives,” PCT Int. Appl. (2002), WO 079268 (A2), Eli Lilly and Company, October 25, 2001.
17. Blaszczak, L. C.; Dingess-Hammond, E. A.; Hornback, W. J.; VanNieuwenhze, M. S. “Preparation of Glucosaminyl-b-[1, 4]-N-Acetylmuramic Acid Derivatives,” PCT Int. Appl. (2001), WO 079267 (A2), Eli Lilly and Company, October 25, 2001.
18. Alborn, Jr., W. E.; Blaszczak, L. C.; Mauldin, S. C.; Skatrud, P. L.; VanNieuwenhze, M. S.; Zia-Ebrahimi, M. S. “Process for Preparing Dansylated Glycopeptide Lipid II Derivatives as Substrates for the Transglycosylase Enzymes,” PCT Intl. Appl. (2001), WO 079267 (A2), Eli Lilly and Company, October 25, 2001
19. Ambler, S. J.; Baker, S. R.; Clark, B. P.; Goldsworthy, J.; Johnson, K.; Kingston, A. E.; Owton, W. M.; Coleman, D. S.; Fogelsong, R. J.; Jagdmann, Jr. G. E.; Schoepp, D. D.; Hong, J. E.; Schkeryantz, J. M.; VanNieuwenhze, M. S.; Zia-Ebrahimi, M. S.  “Preparation of Heterocycles Containing a 4-Substituted Pyrimidine Subunit for Pharmaceutical Use as mGluR1 Antagonists” PCT Int. Appl. (2001), WO 032632 (A2), Eli Lilly and Company, May 5, 2001.

---

Issued Patents

1. Zlotnick, A.; Li, L.; VanNieuwenhze, M. S.; Turner, W. W., “Fluorescent-HAP: A Diagnostic Stain for HBV Cores in Cells,” United States Patent No. 10,006,913; Indiana University research and Technology Corporation, June 26, 2018.
2. VanNieuwenhze, M. S.; Turner, W. W.; Witztum, J. L.; Hartvigsen, K. “Peptide-Phospholipid Conjugates,” United Sates Patent No. 9,518,088; Indiana University Research and Technology Corporation, December 13, 2016.
3. Blaszczak, L. C.; Dingess-Hammond, E. A.; Hornback, W. J.; VanNieuwenhze, M. S., “Glycopeptide and Preparation Thereof” United States Patent No. 7,173,107; Eli Lilly and Company, February 6, 2007.
4. Alborn, Jr., W. E.; Blaszczak, L. C.; Mauldin, S. C.; Skatrud, P. L.; VanNieuwenhze, M. S.; Zia-Ebrahimi, M. S., “Process for Preparing Lipid II,” United States Patent No. 7,169,919; Eli Lilly and Company, January 30, 2007.
5. VanNieuwenhze, M. S.; Spitzer, W. A.; Schladetzky, K. D., “Preparation of Pyridoimidazoles as Antiviral Agents” United States Patent No. 6,087,374; Eli Lilly and Company, July 11, 2000.